Downregulated miRNA-1269a variant

Downregulated miRNA-1269a variant

Although emerging evidence has indicated that single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) are associated with susceptibility to gastric cancer, a limited number of studies have revealed the underlying molecular mechanisms. In the present study, the results suggested that miR-1269a r...

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Veröffentlicht in:Oncology letters 2017-12, Vol.14 (6), p.6345
Hauptverfasser: Shi, Jianping, Zhang, Jun, Li, Wenshuai, Liu, Jie, Xu, Weihong, Yang, Dongqin, Jiang, Weiru, Ma, Yanyun, Zhang, Huilu, Zhang, Mingqing, Zhu, Jie, Li, Min, Qiu, Jigang, Xu, Diannan, Chen, Jian, Min, Pei
Format: Artikel
Sprache:eng
Schlagworte:
Care and treatment
Development and progression
Gene expression
Genetic aspects
Genetic variation
Health aspects
MicroRNA
Stomach cancer
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Zusammenfassung:Although emerging evidence has indicated that single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) are associated with susceptibility to gastric cancer, a limited number of studies have revealed the underlying molecular mechanisms. In the present study, the results suggested that miR-1269a rs73239138 has a role in decreasing the risk of gastric cancer. The level of miR-1269a variant expression was significantly downregulated compared with the wild-type miR-1269a in the gastric cells (Fig. 1). Furthermore, overexpression of miR-1269a inhibited apoptosis of gastric cancer cells.
ISSN:1792-1074