Recombinant Human Bone Morphogenetic Protein-2

Recombinant human bone morphogenetic protein-2 with an additional s-tag domain (s-tagBMP-2) synthesized in E. coli is characterized by higher solubility and activity than the protein without additional s-tag domain, which increases the yield during purification and simplifies protein introduction into the osteoplastic materials. The high osteoinductivity of the demineralized bone matrix with s-tag-BMP-2 was shown on the model of regeneration of cranial defects of a critical size in mice and on the model of implantation of porous titanium matrix into defects of femoral and tibial bones in rabbits. Key Words: rhBMP-2; demineralized bone matrix; regeneration of bone tissue; critical size defect; titanium implants