LC–MS/MS bioanalytical method for quantification of binimetinib and venetoclax, and their pharmacokinetic interaction

LC–MS/MS bioanalytical method for quantification of binimetinib and venetoclax, and their pharmacokinetic interaction

Because of several prospective benefits, binimetinib (BMT)-venetoclax (VTC) combination can be a better therapeutic strategy to treat cancer. An LC–MS/MS method for simultaneous quantification of BMT and VTC in rat plasma has been developed and validated. Specificity, accuracy, precision and stabili...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Bioanalysis 2022-01, Vol.14 (2), p.75-86
Hauptverfasser: Reddy, Anuradha, Jadav, Tarang, Sahu, Amit Kumar, Sengupta, Pinaki
Format: Artikel
Sprache:eng
Schlagworte:
binimetinib
bioanalysis
Biochemical Research Methods
Biochemistry & Molecular Biology
Chemistry
Chemistry, Analytical
LC–MS/MS
Life Sciences & Biomedicine
pharmacokinetic interaction
Physical Sciences
Science & Technology
venetoclax
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Because of several prospective benefits, binimetinib (BMT)-venetoclax (VTC) combination can be a better therapeutic strategy to treat cancer. An LC–MS/MS method for simultaneous quantification of BMT and VTC in rat plasma has been developed and validated. Specificity, accuracy, precision and stability results met the acceptance criteria for validation. Accuracy and precisions at all quality control levels were
ISSN:1757-6180
1757-6199
DOI:10.4155/bio-2021-0207