In focus: Fe

The growing implementation of iron oxide nanoparticles in medicine requires a thorough investigation of their physiological influence. Therefore, effects of Fe O nanoparticles on isometric contractions of healthy human mesenteric artery were investigated. The effect of increasing concentrations (0.023, 0.069, 0.23, 0.69 and 2.31 μg/μl) of Fe O nanoparticles (50-100 nm) on the contractility of mesenteric artery ring preparations was studied using wire myography technique. A lack of effects of Fe O nanoparticles (50-100 nm) on isometric contractions of human mesenteric artery segments both in conditions of basal tension and precontraction was found. The observed unresponsiveness of human mesenteric arteries to Fe O nanoparticles could be attributed to their safe mode of use in biomedicine.