Pentamidine inhibits the growth of

The purpose of this study was to evaluate the effects of the antileishmanials meglumine antimoniate and pentamidine against complex. The antifungal activity of the two antileishmanials was assessed by broth microdilution. The interaction between the antileishmanials and antifungal drugs (amphotericin B, itraconazole and terbinafine) was evaluated by the checkerboard assay. The effect of prior exposure of spp. yeast cells to antileishmanials was evaluated by broth microdilution. Only pentamidine showed antifungal activity against spp. Synergistic interactions were observed between pentamidine and the antifungals. Also, the pre-exposure to meglumine antimoniate reduced the susceptibility of and to amphotericin B and itraconazole. Pentamidine showed antifungal activity against spp., indicating it is a possible therapeutic alternative for the treatment of sporotrichosis.