Activity of 3′-hydroxychalcone against

This work aimed to evaluate the activity of 3′-hydroxychalcone against in planktonic and biofilm forms and their toxicity using alternative animal models. Minimum inhibitory concentration and minimum fungicide concentration were determined. Biofilm formation and the susceptibility tests were performed by the 2,3- -(2-methoxy-4-nitro-5-sulfophenyl)-5-[carbonyl(phenylamino)]-2 -tetrazolium hydroxide assay. Toxicity and efficacy were checked in and models. The compound 3′-hydroxychalcone showed fungicidal activity against in both planktonic and biofilm forms. The toxicity in zebrafish embryos revealed a low lethal concentration. In , the compound did not show antifungal activity and larvae toxicity. Because of the activity of 3′-hydroxychalcone against , molecular modifications should be made to improve efficacy and to reduce toxicity .