Clinical significance of detecting

To investigate the clinical significance of detecting several biomarkers collectively in the diagnosis of rheumatoid arthritis (RA). 128 RA patients, 174 non-RA patients and 80 healthy controls were enrolled. 4 and 53 were detected by the PCR-SSP method, 14-3-3η protein, anti-CCP and anti-Sa were de...

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Veröffentlicht in:Biomarkers in medicine 2018-07, Vol.12 (7), p.697-705
Hauptverfasser: Tan, Liming, Wang, Qiaohua, Zeng, Tingting, Long, Tingting, Guan, Xiaolin, Wu, Sifan, Zheng, Wei, Fu, Huiying, Meng, Yimei, Wu, Yang, Tian, Yongjian, Yu, Jianlin, Chen, Juanjuan, Li, Hua, Cao, Liping
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Sprache:eng
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Zusammenfassung:To investigate the clinical significance of detecting several biomarkers collectively in the diagnosis of rheumatoid arthritis (RA). 128 RA patients, 174 non-RA patients and 80 healthy controls were enrolled. 4 and 53 were detected by the PCR-SSP method, 14-3-3η protein, anti-CCP and anti-Sa were detected by ELISA and DD was detected by latex immunoturbidimetric assay. The positive rates of 4, 53, 14-3-3η protein, anti-CCP and anti-Sa were obviously higher in the RA group (43.8, 38.3, 51.6, 80 and 40.6%, respectively); anti-CCP was of highest sensitivity (79.68%), highest specificity (97.5%) and Youden index (0.77). The AUC of 14-3-3η protein, DD, anti-CCP, anti-Sa were 0.813, 0.859, 0.930, 0.861, respectively. All biomarkers were strongly correlated risk factors for RA; the combination of multiple biomarkers might be of help for diagnostic and therapeutic strategies in RA of recent onset.
ISSN:1752-0363
1752-0371
DOI:10.2217/bmm-2017-0371