Clinical significance of detecting
To investigate the clinical significance of detecting several biomarkers collectively in the diagnosis of rheumatoid arthritis (RA). 128 RA patients, 174 non-RA patients and 80 healthy controls were enrolled. 4 and 53 were detected by the PCR-SSP method, 14-3-3η protein, anti-CCP and anti-Sa were de...
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Veröffentlicht in: | Biomarkers in medicine 2018-07, Vol.12 (7), p.697-705 |
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Sprache: | eng |
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Zusammenfassung: | To investigate the clinical significance of detecting several biomarkers collectively in the diagnosis of rheumatoid arthritis (RA).
128 RA patients, 174 non-RA patients and 80 healthy controls were enrolled.
4 and
53 were detected by the PCR-SSP method, 14-3-3η protein, anti-CCP and anti-Sa were detected by ELISA and DD was detected by latex immunoturbidimetric assay.
The positive rates of
4,
53, 14-3-3η protein, anti-CCP and anti-Sa were obviously higher in the RA group (43.8, 38.3, 51.6, 80 and 40.6%, respectively); anti-CCP was of highest sensitivity (79.68%), highest specificity (97.5%) and Youden index (0.77). The AUC of 14-3-3η protein, DD, anti-CCP, anti-Sa were 0.813, 0.859, 0.930, 0.861, respectively.
All biomarkers were strongly correlated risk factors for RA; the combination of multiple biomarkers might be of help for diagnostic and therapeutic strategies in RA of recent onset. |
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ISSN: | 1752-0363 1752-0371 |
DOI: | 10.2217/bmm-2017-0371 |