Differential Shedding and Antibody Kinetics of Zika and Chikungunya Viruses, Brazil

Differential Shedding and Antibody Kinetics of Zika and Chikungunya Viruses, Brazil

In seroconversion panels obtained from patients from Brazil, diagnostic testing for Zika virus infection was improved by combining multiple antibody isotypes, techniques, and antigens, but sensitivity remained suboptimal. In contrast, chikungunya virus diagnostic testing was unambiguous. Recurrent r...

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Hauptverfasser: Bozza, Fernando A, Moreira-Soto, Andres, Rockstroh, Alexandra, Fischer, Carlo, Nascimento, Alessandra D, Calheiros, Andrea S, Drosten, Christian, Bozza, Patrícia T, Souza, Thiago Moreno L, Ulbert, Sebastian, Drexler, Jan Felix
Format: Artikel
Sprache:eng
Schlagworte:
Chikungunya virus
virus disease
Viruses
Zika virus
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Zusammenfassung:In seroconversion panels obtained from patients from Brazil, diagnostic testing for Zika virus infection was improved by combining multiple antibody isotypes, techniques, and antigens, but sensitivity remained suboptimal. In contrast, chikungunya virus diagnostic testing was unambiguous. Recurrent recent arbovirus infections suggested by serologic data and unspecific symptoms highlight the need for exhaustive virologic testing.
DOI:10.3201/eid2502.180166