The nitric oxide-savenging properties of ginkgo biloba extract EGb 761

The nitric oxide-savenging properties of ginkgo biloba extract EGb 761

Ginkgo biloba extract EGb 761 was found to be a scavenger of nitric oxide in in vitro acellular systems, under physiological conditions. EGb 761 competed with oxyhemoglobin for reaction with nitric oxide generated during the interaction of hydroxylamine with Complex I of catalase. An EGb 761 dose-de...

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Veröffentlicht in:Biochemical and biophysical research communications 1994-06, Vol.210 (2)
Hauptverfasser: Marcocci, L, Maguire, J.J, Droy-Lefaix, M.T, Packer, L
Format: Artikel
Sprache:eng
Schlagworte:
CONTAMINANTES
EXTRACTOS VEGETALES
EXTRAIT D'ORIGINE VEGETALE
GINKGO BILOBA
OXIDACION
OXIDOS DE NITROGENO
OXYDATION
OXYDE D'AZOTE
POLLUANT
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Zusammenfassung:Ginkgo biloba extract EGb 761 was found to be a scavenger of nitric oxide in in vitro acellular systems, under physiological conditions. EGb 761 competed with oxyhemoglobin for reaction with nitric oxide generated during the interaction of hydroxylamine with Complex I of catalase. An EGb 761 dose-dependent decrease in the amount of nitrite formed in the reaction of oxygen with nitric oxide produced from solution of 5 mM sodium nitroprusside was also observed. These data implicate it as a potential therapeutic agent in conditions of altered production of nitric oxide
ISSN:0006-291X
1090-2104