Virulence and Karyotype Analyses of rad52 Mutants of Candida albicans: Regeneration of a Truncated Chromosome of a Reintegrant Strain (rad52/RAD52) in the Host

Virulence and Karyotype Analyses of rad52 Mutants of Candida albicans: Regeneration of a Truncated Chromosome of a Reintegrant Strain (rad52/RAD52) in the Host

10⁶, but there was a decrease in survival time at dosages of1.5 x 10⁶ and especially at 3 x10⁶ cells per animal. The heterozygote RAD52/rad52behaved like wild type, whereas a reintegrant strain was intermediate

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Veröffentlicht in:Infection and Immunity 2005-12, Vol.73 (12), p.8069-8078
Hauptverfasser: Chauhan, Neeraj, Ciudad, Toni, Rodríguez-Alejandre, Ane, Larriba, Germán, Calderone, Richard, Andaluz, Encarnación
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological and medical sciences
Candida albicans
Candida albicans - genetics
Candida albicans - growth & development
Candida albicans - pathogenicity
Candidiasis - parasitology
chromosomes
Chromosomes, Fungal
DNA Ligase ATP
DNA Ligases - genetics
Fundamental and applied biological sciences. Psychology
Fungal and Parasitic Infections
Fungal Proteins - genetics
Gene Deletion
Gene Dosage
Genotype
Heterozygote
Karyotyping
Kidney - parasitology
Kidney - pathology
Mice
Mice, Inbred BALB C
Microbiology
Miscellaneous
mutants
Mutation
Mycology
Rad52 DNA Repair and Recombination Protein - genetics
virulence
Virulence - genetics
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Beschreibung
Zusammenfassung:10⁶, but there was a decrease in survival time at dosages of1.5 x 10⁶ and especially at 3 x10⁶ cells per animal. The heterozygote RAD52/rad52behaved like wild type, whereas a reintegrant strain was intermediate
ISSN:0019-9567
1098-5522
DOI:10.1128/IAI.73.12.8069-8078.2005