CD4+ T cells from elite suppressors are more susceptible to HIV-1 but produce fewer virions than cells from chronic progressors

Elite suppressors/controllers (ES) are HIV-1–infected individuals who maintain stable CD4+ T-cell counts and viral loads of

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Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-09, Vol.108 (37), p.E689-E698
Hauptverfasser:	O'Connell, Karen A, Rabi, S. Alireza, Siliciano, Robert F, Blankson, Joel N
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiretroviral drugs antiretroviral therapy Apoptosis Biological Sciences CD4 antigen CD4-positive T-lymphocytes CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - pathology CD4-Positive T-Lymphocytes - virology Cell Death Chronic Disease Chronic infection Cohort Studies Comparative analysis Data processing death disease course Disease Progression Disease Susceptibility HIV HIV Infections - immunology HIV Infections - virology HIV-1 - immunology Human immunodeficiency virus Human immunodeficiency virus 1 Humans Immunologic Memory - immunology Lymphocyte Activation - immunology Lymphocytes T patients PNAS Plus Replication T cell receptors therapeutics Tissue Donors viral load virion Virion - immunology Virions virus replication viruses
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Beschreibung
Zusammenfassung:	Elite suppressors/controllers (ES) are HIV-1–infected individuals who maintain stable CD4+ T-cell counts and viral loads of
ISSN:	0027-8424 1091-6490
DOI:	10.1073/pnas.1108866108