I222V Neuraminidase Mutation Has a Compensatory Role in Replication of an Oseltamivir-Resistant Influenza Virus A/H3N2 E119V Mutant

Oseltamivir-resistant A/H3N2 influenza isolates with or without the E119V and I222V neuraminidase (NA) mutations were recovered from an immunocompromised patient. Based on plaque size, yield assays, and NA activity, the impaired viral fitness of the E119V mutant was partially restored by the I222V N...

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Veröffentlicht in:	Journal of Clinical Microbiology 2011-02, Vol.49 (2), p.715-717
Hauptverfasser:	Simon, Philippe, Holder, Benjamin P, Bouhy, Xavier, Abed, Yacine, Beauchemin, Catherine A.A, Boivin, Guy
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution - genetics Animals Antiviral Agents - pharmacology Cell Line Dogs Drug Resistance, Viral Humans Immunocompromised Host Influenza A virus Influenza A Virus, H3N2 Subtype - drug effects Influenza A Virus, H3N2 Subtype - isolation & purification Influenza A Virus, H3N2 Subtype - physiology Influenza, Human - virology Mutation, Missense Neuraminidase - genetics Oseltamivir - pharmacology Suppression, Genetic Viral Plaque Assay Viral Proteins - genetics Virology Virus Replication
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Zusammenfassung:	Oseltamivir-resistant A/H3N2 influenza isolates with or without the E119V and I222V neuraminidase (NA) mutations were recovered from an immunocompromised patient. Based on plaque size, yield assays, and NA activity, the impaired viral fitness of the E119V mutant was partially restored by the I222V NA mutation.
ISSN:	0095-1137 1098-660X
DOI:	10.1128/JCM.01732-10