High-Resolution Typing by Integration of Genome Sequencing Data in a Large Tuberculosis Cluster

High-Resolution Typing by Integration of Genome Sequencing Data in a Large Tuberculosis Cluster

To investigate whether genome sequencing yields more useful markers than those currently used to study the epidemiology of tuberculosis, it was applied to three Mycobacterium tuberculosis isolates of the Harlingen outbreak. Our findings suggest that single nucleotide polymorphisms can be used to ide...

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Veröffentlicht in:Journal of Clinical Microbiology 2010-09, Vol.48 (9), p.3403-3406
Hauptverfasser: Schürch, Anita C, Kremer, Kristin, Daviena, Olaf, Kiers, Albert, Boeree, Martin J, Siezen, Roland J, van Soolingen, Dick
Format: Artikel
Sprache:eng
Schlagworte:
Bacterial Typing Techniques
Biological and medical sciences
Cluster Analysis
DNA, Bacterial - chemistry
DNA, Bacterial - genetics
Fundamental and applied biological sciences. Psychology
Genome, Bacterial
Humans
Microbiology
Molecular Epidemiology - methods
Mycobacteriology and Aerobic Actinomycetes
Mycobacterium tuberculosis
Mycobacterium tuberculosis - classification
Mycobacterium tuberculosis - genetics
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide
Tuberculosis - microbiology
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Zusammenfassung:To investigate whether genome sequencing yields more useful markers than those currently used to study the epidemiology of tuberculosis, it was applied to three Mycobacterium tuberculosis isolates of the Harlingen outbreak. Our findings suggest that single nucleotide polymorphisms can be used to identify transmission chains in restriction fragment length polymorphism clusters.
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.00370-10