Glutahione-S-transferase-mediated methylthio displacement and turnover in the metabolism of pentachlorothioanisole by rats

Glutahione-S-transferase-mediated methylthio displacement and turnover in the metabolism of pentachlorothioanisole by rats

The metabolism of pentachlorothioanisole to bis-(methylthio)tetrachlorobenzene was shown to involve turnover of about 50% of the original methylthio group. Metabolites of the displaced methylthio group were methanesulphinic acid and sulphate in the urine, carbon dioxide in the expired air, and unide...

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Veröffentlicht in:Xenobiotica 1991, Vol.21 (5), p.597-603
Hauptverfasser: Mulford, D.J, Bakke, J.E, Feil, V.J
Format: Artikel
Sprache:eng
Schlagworte:
glutathione transferase
hexachlorobenzene
metabolism
metabolites
organic sulfur compounds
quintozene
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Zusammenfassung:The metabolism of pentachlorothioanisole to bis-(methylthio)tetrachlorobenzene was shown to involve turnover of about 50% of the original methylthio group. Metabolites of the displaced methylthio group were methanesulphinic acid and sulphate in the urine, carbon dioxide in the expired air, and unidentified sulphur-containing compounds in the bile.
ISSN:0049-8254
1366-5928