1-alpha-hydroxy-19-nor-vitamin D C-22 aldehyde. A valuable intermediate in the synthesis of side chain modified 1-alpha,25-dihydroxy-19-nor vitamin D3

1-alpha-hydroxy-19-nor-vitamin D C-22 aldehyde. A valuable intermediate in the synthesis of side chain modified 1-alpha,25-dihydroxy-19-nor vitamin D3

A side chain homologated 1alpha, 25-dihydroxy-19-nor-vitamin D3 analog was prepared in a double convergent synthesis with 1alpha-hydroxy-19-nor-vitamin D C-22 aldehyde as a key intermediate.

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Veröffentlicht in:Tetrahedron letters 1992-05, Vol.33 (21), p.2937-2940
Hauptverfasser: Perlman, K.L, Deluca, H.F
Format: Artikel
Sprache:eng
Schlagworte:
bioassays
cholecalciferol
structure-activity relationships
synthesis
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Zusammenfassung:A side chain homologated 1alpha, 25-dihydroxy-19-nor-vitamin D3 analog was prepared in a double convergent synthesis with 1alpha-hydroxy-19-nor-vitamin D C-22 aldehyde as a key intermediate.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(00)79565-7