Susceptibility to Infectious Diseases Based on Antimicrobial Peptide Production

In the last few years, the great impact of antimicrobial peptides on infectious disease susceptibility and natural resistance has been reported. In some cases, susceptibility to diseases is related to antimicrobial peptide polymorphisms and gene copy numbers, but for the vast majority of infectious...

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Veröffentlicht in:	Infection and Immunity 2009-11, Vol.77 (11), p.4690-4695
Hauptverfasser:	Rivas-Santiago, Bruno, Serrano, Carmen J, Enciso-Moreno, J. Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimicrobial Cationic Peptides - genetics Antimicrobial Cationic Peptides - immunology Biological and medical sciences Communicable Diseases - genetics Communicable Diseases - immunology Fundamental and applied biological sciences. Psychology Genetic Predisposition to Disease Humans Microbiology Minireview
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Beschreibung
Zusammenfassung:	In the last few years, the great impact of antimicrobial peptides on infectious disease susceptibility and natural resistance has been reported. In some cases, susceptibility to diseases is related to antimicrobial peptide polymorphisms and gene copy numbers, but for the vast majority of infectious diseases, these phenomena need to be elucidated. This review is focused on the current knowledge about susceptibility and resistance conferred by genetic variations in antimicrobial peptide expression in infectious diseases.
ISSN:	0019-9567 1098-5522
DOI:	10.1128/IAI.01515-08