Evidence for involvement of equine herpesvirus 1 glyprotein B in cell-cell fusion

Evidence for involvement of equine herpesvirus 1 glyprotein B in cell-cell fusion

Monoclonal antibodies specific for equine herpesvirus 1 (EHV-1) glycoproteins (gB, gD, gp2 and a cleaved translation product of gene 71) were tested for ability to inhibit cell-cell fusion as measured by syncytium formation in EHV-1 infected cell cultures. Syncytium formation was inhibited by a comp...

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Veröffentlicht in:Archives of virology 1996, Vol.141 (1), p.167-175
Hauptverfasser: Wellington, J.E, Love, D.N, Whalley, J.M
Format: Artikel
Sprache:eng
Schlagworte:
cells
cultured cells
equine herpesvirus
glycoproteins
induced cell fusion
monoclonal antibodies
syncytium formation
viral antigens
virus neutralization
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Zusammenfassung:Monoclonal antibodies specific for equine herpesvirus 1 (EHV-1) glycoproteins (gB, gD, gp2 and a cleaved translation product of gene 71) were tested for ability to inhibit cell-cell fusion as measured by syncytium formation in EHV-1 infected cell cultures. Syncytium formation was inhibited by a complement-dependent neutralising antibody (7B10) which recognised the large subunit of EHV-1 gB. This indicated that EHV-1 gB, in common with gB homologues of herpes simplex virus and other herpesviruses, plays a role in the cell-cell fusion process.
ISSN:0304-8608
1432-8798