Molecular Analysis of tet(W) Gene-Mediated Tetracycline Resistance in Dominant Intestinal Bifidobacterium Species from Healthy Humans

tet(W) was found responsible for tetracycline resistance (MICs, 4 to >=32 μg ml⁻¹) in dominant bifidobacterial species from the gastrointestinal tracts of healthy humans. The gene from Bifidobacterium longum H66 proved to be identical over a 2.6-kbp region to the recently described tet(W) determi...

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Veröffentlicht in:	Applied and Environmental Microbiology 2006-11, Vol.72 (11), p.7377-7379
Hauptverfasser:	Flórez, Ana Belén, Ammor, Mohammed Salim, Álvarez-Martín, Pablo, Margolles, Abelardo, Mayo, Baltasar
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Bacteria Bacterial Proteins - genetics Bifidobacterium Bifidobacterium - classification Bifidobacterium - drug effects Bifidobacterium - genetics Bifidobacterium - isolation & purification Bifidobacterium longum Biological and medical sciences Butyrivibrio - drug effects Butyrivibrio - genetics Butyrivibrio fibrisolvens Drug resistance Feces - microbiology Fundamental and applied biological sciences. Psychology Gene expression Humans Microbial Ecology Microbial Sensitivity Tests Microbiology Molecular Sequence Data Molecular structure Phylogeny Sequence Analysis, DNA Tetracycline - pharmacology Tetracycline Resistance - genetics
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Zusammenfassung:	tet(W) was found responsible for tetracycline resistance (MICs, 4 to >=32 μg ml⁻¹) in dominant bifidobacterial species from the gastrointestinal tracts of healthy humans. The gene from Bifidobacterium longum H66 proved to be identical over a 2.6-kbp region to the recently described tet(W) determinant of Butyrivibrio fibrisolvens.
ISSN:	0099-2240 1098-5336
DOI:	10.1128/AEM.00486-06