Iron Efflux Protein Ferroportin Regulates the Intracellular Growth of Salmonella enterica

We investigated the influence of the macrophage iron exporter ferroportin and its ligand hepcidin on intracellular Salmonella growth. Elevated ferroportin expression inhibited bacterial multiplication; hepcidin-induced ferroportin down-regulation enhanced it. Expression analysis of iron-responsive S...

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Veröffentlicht in:	Infection and Immunity 2006-05, Vol.74 (5), p.3065-3067
Hauptverfasser:	Chlosta, Sabine, Fishman, Douglas S, Harrington, Lynne, Johnson, Erin E, Knutson, Mitchell D, Wessling-Resnick, Marianne, Cherayil, Bobby J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimicrobial Cationic Peptides - physiology Bacteriology Biological and medical sciences Cation Transport Proteins - physiology Cell Line Cellular Microbiology: Pathogen-Host Cell Molecular Interactions Fundamental and applied biological sciences. Psychology Hepcidins Iron - metabolism Macrophages - microbiology Mice Microbiology Miscellaneous Salmonella enterica Salmonella enterica - growth & development
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Zusammenfassung:	We investigated the influence of the macrophage iron exporter ferroportin and its ligand hepcidin on intracellular Salmonella growth. Elevated ferroportin expression inhibited bacterial multiplication; hepcidin-induced ferroportin down-regulation enhanced it. Expression analysis of iron-responsive Salmonella genes indicated ferroportin-mediated iron deprivation. These results demonstrate a role for ferroportin in antimicrobial resistance.
ISSN:	1098-5522 0019-9567 1098-5522
DOI:	10.1128/IAI.74.5.3065-3067.2006