Bifidobacterium longum NCIMB 702259[superscript T] ctr Gene Codes for a Novel Cholate Transporter

Bifidobacterium longum NCIMB 702259[superscript T] ctr Gene Codes for a Novel Cholate Transporter

Preexposure of Bifidobacterium longum NCIMB 702259[superscript T] to cholate caused increased resistance to cholate, chloramphenicol, and erythromycin. The B. longum ctr gene, encoding a cholate efflux transporter, was transformed into the efflux-negative mutant Escherichia coli KAM3, conferring res...

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Veröffentlicht in:Applied and environmental microbiology 2006, Vol.72 (1), p.923-926
Hauptverfasser: Price, Claire E, Reid, Sharon J, Driessen, Arnold J. M, Abratt, Valerie R
Format: Artikel
Sprache:eng
Schlagworte:
amino acid sequences
Bifidobacterium longum
bile salts
biological resistance
cholic acid
ctr gene
genes
glycocholic acid
molecular sequence data
nucleotide sequences
physiological transport
probiotics
stress tolerance
transporters
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Zusammenfassung:Preexposure of Bifidobacterium longum NCIMB 702259[superscript T] to cholate caused increased resistance to cholate, chloramphenicol, and erythromycin. The B. longum ctr gene, encoding a cholate efflux transporter, was transformed into the efflux-negative mutant Escherichia coli KAM3, conferring resistance to bile salts and other antimicrobial compounds and causing the efflux of [¹⁴C]cholate.
ISSN:0099-2240
1098-5336
DOI:10.1128/AEM.72.1.923-926.2006