Toll-Like Receptor 2 Deficiency Delays Pneumococcal Phagocytosis and Impairs Oxidative Killing by Granulocytes

Phagocytosis and killing of Streptococcus pneumoniae was compared in blood-derived wild-type (WT) and Toll-like receptor 2 (TLR2)-deficient (TLR2[superscript -/-]) polymorphonuclear leukocytes (PMN). Phagocytosis of green fluorescent protein-transformed pneumococci was delayed in TLR2[superscript -/...

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Veröffentlicht in:	Infection and Immunity 2005-12, Vol.73 (12), p.8397-8401
Hauptverfasser:	Letiembre, Maryse, Echchannaoui, Hakim, Bachmann, Philipp, Ferracin, Fabrizia, Nieto, Concepción, Espinosa, Manuel, Landmann, Regine
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteriology Biological and medical sciences Cells, Cultured Fundamental and applied biological sciences. Psychology Granulocytes - chemistry Granulocytes - immunology Granulocytes - microbiology Green Fluorescent Proteins - analysis Host Response and Inflammation Mice Mice, Knockout Microbiology Miscellaneous Oxidation-Reduction Phagocytosis - genetics Streptococcus pneumoniae Streptococcus pneumoniae - immunology Toll-Like Receptor 2 - deficiency Toll-Like Receptor 2 - genetics
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Beschreibung
Zusammenfassung:	Phagocytosis and killing of Streptococcus pneumoniae was compared in blood-derived wild-type (WT) and Toll-like receptor 2 (TLR2)-deficient (TLR2[superscript -/-]) polymorphonuclear leukocytes (PMN). Phagocytosis of green fluorescent protein-transformed pneumococci was delayed in TLR2[superscript -/-] PMN. These cells exhibited also a lower oxidative bactericidal activity against S. pneumoniae than WT PMN, suggesting that TLR2 modulates bacterial clearance in PMN.
ISSN:	0019-9567 1098-5522
DOI:	10.1128/IAI.73.12.8397-8401.2005