Development of Daptomycin Resistance In Vivo in Methicillin-Resistant Staphylococcus aureus

Daptomycin is a new lipopeptide antibiotic that is rapidly bactericidal against Staphylococcus aureus. We report daptomycin resistance and treatment failure in 2 patients with osteomyelitis due to methicillin-resistant S. aureus. Disk diffusion susceptibility testing failed to detect resistance. Dap...

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Veröffentlicht in:	Journal of Clinical Microbiology 2005-10, Vol.43 (10), p.5285-5287
Hauptverfasser:	Hayden, M. K, Rezai, K, Hayes, R. A, Lolans, K, Quinn, J. P, Weinstein, R. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Bacteremia - microbiology Bacteriology Biological and medical sciences Daptomycin - pharmacology Drug Resistance, Bacterial Female Fundamental and applied biological sciences. Psychology Humans Infectious diseases Lumbar Vertebrae - microbiology Lumbosacral Region - microbiology Medical sciences Methicillin Resistance Microbial Sensitivity Tests - methods Microbiology Middle Aged Miscellaneous Osteomyelitis - microbiology Staphylococcal Infections - microbiology Staphylococcus aureus - drug effects Treatment Failure
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Beschreibung
Zusammenfassung:	Daptomycin is a new lipopeptide antibiotic that is rapidly bactericidal against Staphylococcus aureus. We report daptomycin resistance and treatment failure in 2 patients with osteomyelitis due to methicillin-resistant S. aureus. Disk diffusion susceptibility testing failed to detect resistance. Daptomycin at high concentration retained bactericidal activity against resistant isolates.
ISSN:	0095-1137 1098-660X
DOI:	10.1128/JCM.43.10.5285-5287.2005