Influence of Disk Preparation on Detection of Metallo-β-Lactamase-Producing Isolates by the Combined Disk Assay

The combined disk assay has been used for detection of metallo-β-lactamase-producing isolates. We have observed that the size of inhibition zones produced by many β-lactam/metallo-β-lactamase inhibitor (IMBL) combinations may differ depending on the way that the combined disks were prepared. Among t...

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Veröffentlicht in:	Journal of Clinical Microbiology 2007-06, Vol.45 (6), p.2058-2060
Hauptverfasser:	Andrade, Soraya S, Picão, Renata C, Campana, Eloiza H, Nicoletti, Adriana G, Pignatari, Antônio C.C, Gales, Ana C
Format:	Artikel
Sprache:	eng
Schlagworte:	Agar Anti-Bacterial Agents - pharmacology Bacteriology beta-Lactam Resistance beta-Lactamase Inhibitors beta-Lactamases - biosynthesis Biological and medical sciences Carbapenems - pharmacology Ceftazidime - pharmacology Culture Media Fundamental and applied biological sciences. Psychology Gram-Negative Bacteria - drug effects Gram-Negative Bacteria - enzymology Gram-Negative Bacteria - isolation & purification Humans Imipenem - pharmacology Infectious diseases Medical sciences Microbial Sensitivity Tests - instrumentation Microbial Sensitivity Tests - methods Microbiology
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Zusammenfassung:	The combined disk assay has been used for detection of metallo-β-lactamase-producing isolates. We have observed that the size of inhibition zones produced by many β-lactam/metallo-β-lactamase inhibitor (IMBL) combinations may differ depending on the way that the combined disks were prepared. Among the 10 β-lactam/IMBL combinations tested, only the imipenem/EDTA combination produced similar results.
ISSN:	0095-1137 1098-660X
DOI:	10.1128/JCM.02467-06