Subtyping Method for Escherichia coli Shiga Toxin (Verocytotoxin) 2 Variants and Correlations to Clinical Manifestations

Shiga toxin 2 (Stx2) from Shiga toxin-producing Escherichia coli (STEC) was subtyped by a method involving partial sequencing of the stxAB₂ operon. Of 255 strains from the Danish STEC cohort, all 20 cases of hemolytic-uremic syndrome were associated with subtype Stx2 (11 cases), subtype Stx2c (1 cas...

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Veröffentlicht in:	Journal of Clinical Microbiology 2007-06, Vol.45 (6), p.2020-2024
Hauptverfasser:	Persson, Søren, Olsen, Katharina E.P, Ethelberg, Steen, Scheutz, Flemming
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Bacteriology Biological and medical sciences Child Denmark Diarrhea - microbiology Diarrhea - physiopathology Escherichia coli Escherichia coli - classification Escherichia coli - genetics Escherichia coli - pathogenicity Escherichia coli Infections - microbiology Escherichia coli Infections - physiopathology Fundamental and applied biological sciences. Psychology Genetic Variation Hemolytic-Uremic Syndrome - microbiology Hemolytic-Uremic Syndrome - physiopathology Humans Infectious diseases Medical sciences Microbiology Miscellaneous Molecular Sequence Data Operon Phylogeny Sequence Analysis, DNA Shiga Toxin 2 - chemistry Shiga Toxin 2 - classification Shiga Toxin 2 - genetics Shiga Toxin 2 - metabolism
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Zusammenfassung:	Shiga toxin 2 (Stx2) from Shiga toxin-producing Escherichia coli (STEC) was subtyped by a method involving partial sequencing of the stxAB₂ operon. Of 255 strains from the Danish STEC cohort, all 20 cases of hemolytic-uremic syndrome were associated with subtype Stx2 (11 cases), subtype Stx2c (1 case), or the two combined (8 cases).
ISSN:	0095-1137 1098-660X 1098-5530
DOI:	10.1128/JCM.02591-06