Cytotoxic constituents from Butea superba Roxb

Cytotoxic constituents from Butea superba Roxb

A carpin (3-hydroxy-9-methoxypterocarpan) (Medicarpin) (1) and four isoflavones, 7-hydroxy-4'-methoxy-isoflavone (Formononetin) (2); 7,4'-dimethoxyisoflavone (3); 5,4'-dihydroxy-7-methoxy-isoflavone (Prunetin) (4) and 7-hydroxy-6,4'-dimethoxyisoflavone (5) were isolated from the...

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Veröffentlicht in:Journal of ethnopharmacology 2007, Vol.109 (19), p.354-358
Hauptverfasser: Ngamrojanavanich, N, Loontaisong, A, Pengpreecha, S, Cherdshewasart, W, Pornpakakul, S, Pudhom, K, Roengsumran, S, Petsom, A
Format: Artikel
Sprache:eng
Schlagworte:
antineoplastic agents
Butea
Butea superba
carpins
chemical constituents of plants
cytotoxicity
human cell lines
isoflavones
medicinal plants
medicinal properties
plant extracts
roots
tubers
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Zusammenfassung:A carpin (3-hydroxy-9-methoxypterocarpan) (Medicarpin) (1) and four isoflavones, 7-hydroxy-4'-methoxy-isoflavone (Formononetin) (2); 7,4'-dimethoxyisoflavone (3); 5,4'-dihydroxy-7-methoxy-isoflavone (Prunetin) (4) and 7-hydroxy-6,4'-dimethoxyisoflavone (5) were isolated from the tuber roots of Butea superba Roxb. Compounds 2 and 4 showed moderate cytotoxic activity on KB cell lines with IC50 (μM) values of 37.3 ± 2.5 and 71.1 ± 0.8 and on BC cell lines with IC50 (μM) values of 32.7 ± 1.5 and 47.3 ± 0.3, respectively.
ISSN:0378-8741
1872-7573