Genetically modified ruminal bacteria protect sheep from fluoroacetate poisoning

Four strains of Butyrivibrio fibrisolvens, transformed with a gene encoding fluoroacetate dehalogenase, maintained a combined population of 10(6) to 10(7) cells ml-1 in the rumens of test sheep. Five inoculated sheep showed markedly reduced toxicological symptoms after fluoroacetate poisoning when b...

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Veröffentlicht in:	Applied and Environmental Microbiology 1998-09, Vol.64 (9), p.3496-3498
Hauptverfasser:	Gregg, K. (Murdoch University, Murdoch, Western Australia, Australia.), Hamdorf, B, Henderson, K, Kopecny, J, Wong, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal productions Animals BACTERIA Biological and medical sciences Biotechnology Butyrivibrio fibrisolvens COMPOSE ORGANOFLUORE COMPUESTO ORGANICO DEL FLUOR Fluoroacetates - poisoning FLUOROACETIC ACID Fundamental and applied biological sciences. Psychology Genes Genetic engineering Genetic technics Genetics Gram-Negative Anaerobic Straight, Curved, and Helical Rods - enzymology Gram-Negative Anaerobic Straight, Curved, and Helical Rods - genetics Hydrolases - genetics Hydrolases - metabolism Methods. Procedures. Technologies MICROORGANISME DU RUMEN MICROORGANISMOS DEL RUMEN Modification of gene expression level ORGANOFLUORINE COMPOUNDS Physiology and Biotechnology Plasmids Poisoning - prevention & control Poisoning - veterinary Poisons Recombinant Proteins - metabolism Rumen - microbiology RUMEN MICROORGANISMS Sheep Sheep Diseases - chemically induced Sheep Diseases - prevention & control Stomach Terrestrial animal productions Toxicology Transformation, Bacterial Vertebrates
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Beschreibung
Zusammenfassung:	Four strains of Butyrivibrio fibrisolvens, transformed with a gene encoding fluoroacetate dehalogenase, maintained a combined population of 10(6) to 10(7) cells ml-1 in the rumens of test sheep. Five inoculated sheep showed markedly reduced toxicological symptoms after fluoroacetate poisoning when behavioral, physiological, and histological effects were compared with those of five uninoculated control sheep
ISSN:	0099-2240 1098-5336
DOI:	10.1128/aem.64.9.3496-3498.1998