Y-chromosomal delections - a risk factor for male infertility

In this study, contribution of micro-deletion towards male infertility among Pakistani male individuals has been described. Our analyses involved evaluation of seven genetic markers spanning the AZFa, b and c region among infertile males and observed micro-deletions were compared with the control healthy fertile counterparts. Data revealed AZFa deletion in 2% infertile azoospermic and oligospermic males, while the AZFb and AZFc deletions were found in 3.8 and 5.8% infertile males, of the total with male respectively. These deletions were found solely in non-obstructive azoospermic patients, which consisted of 17.6% non-obstructive infertile males. Our data clearly demonstrate association of Y-chromosomal micro-deletions infertility.