Effect of Metabolic Structures and Energy Requirements on Curdlan Production by Alcaligenes faecalis

Effect of Metabolic Structures and Energy Requirements on Curdlan Production by Alcaligenes faecalis

A comprehensive metabolic network was proposed for Alcaligenes faecalis and employed in a stoichiometrically based flux balance model for curdlan production optimization. The maximal yield of curdlan was evaluated for curdlan batch production. Various metabolic structures and metabolic pathway distr...

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Veröffentlicht in:Biotechnology and bioprocess engineering 2007-07, Vol.12 (4)
Hauptverfasser: Zheng, Zhi-Yong (Yangtze University, Wuxi, P. R. China), Lee, J.W. (Yangtze University, Wuxi, P. R. China), Zhan, Xiao Bei (Yangtze University, Wuxi, P. R. China), E-mail: xbzhan@yahoo.com, Shi, Zhongping (Yangtze University, Wuxi, P. R. China), Wang, Lei (Yangtze University, Wuxi, P. R. China), Zhu, Li (Yangtze University, Wuxi, P. R. China), Wu, Jian-Rong (Yangtze University, Wuxi, P. R. China), Lin, Chi Chung (Yangtze University, Wuxi, P. R. China)
Format: Artikel
Sprache:eng
Schlagworte:
ALCALIGENES FAECALIS
bioenergetics
curdlan
metabolic flux analysis
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Zusammenfassung:A comprehensive metabolic network was proposed for Alcaligenes faecalis and employed in a stoichiometrically based flux balance model for curdlan production optimization. The maximal yield of curdlan was evaluated for curdlan batch production. Various metabolic structures and metabolic pathway distributions related with the curdlan maximal yield was evaluated. The results showed that the energy efficiency rather than the substrate supply was the major constraint for the enhancement of curdlan production.
ISSN:1226-8372
1976-3816
DOI:10.1007/BF02931057