Oral Repeated-dose Toxicity Studies Especially in the Liver and Kidney of Rats Administered with Organic Germanium-fortified Yeast

The object of this study was to examine whether the germanium fortified yeast administered to SD rat is accumulated in the liver and kidney. The administration dases were within 2,000 mg/kg which is the level of NOAEL (no observed adverse effect level) proved through the previous study of single/consecutive oral toxicity test. There were no significant clinical symptoms and morptality following the administration of organic germanium-fortified yeast (0, 500, 1,000, 2,000 mg/k) during the whole test period, and also no difference in the coucumed amount of feed and water for each group.