Isolation of Melanogenesis Inhibitors from Ponciri Fructus

Isolation of Melanogenesis Inhibitors from Ponciri Fructus

To develop an whitening cosmetics, we isolated the melanogenesis inhibitors from the unripe fruits of Poncirus trifoliata (Rutaceae). Isolated compounds were identified as poncirin(1), naringin(2), bis(2-methylheptyl)phthalate(3), avenalumic acid methyl ester(4) by comparison of physical and spectra...

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Veröffentlicht in:Korean Journal of Pharmacognosy 2005-03, Vol.36 (1)
Hauptverfasser: Son, A.R. (Yeungnam University, Kyoungsan, Republic of Korea), Choi, J.Y. (Yeungnam University, Kyoungsan, Republic of Korea), Kim, J.A. (Yeungnam University, Kyoungsan, Republic of Korea), Cho, S.H. (Yeungnam University, Kyoungsan, Republic of Korea), Hua, Xu Guang (Yeungnam University, Kyoungsan, Republic of Korea), Park, S.H. (Yeungnam University, Kyoungsan, Republic of Korea), Chung, S.R. (Yeungnam University, Kyoungsan, Republic of Korea), Chung, T.C. (Yeungnam University, Kyoungsan, Republic of Korea), Jahng, Y.D. (Yeungnam University, Kyoungsan, Republic of Korea), Son, J.K. (Yeungnam University, Kyoungsan, Republic of Korea), Lee, S.H. (Yeungnam University, Kyoungsan, Republic of Korea), E-mail: seungho@yu.ac.kr
Format: Artikel
Sprache:kor
Schlagworte:
bis(2-methylheptyl)phthalate
melanogenesis inhibitors
PONCIRUS TRIFOLIATA
RUTACEAE
whitening cosmetics
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Zusammenfassung:To develop an whitening cosmetics, we isolated the melanogenesis inhibitors from the unripe fruits of Poncirus trifoliata (Rutaceae). Isolated compounds were identified as poncirin(1), naringin(2), bis(2-methylheptyl)phthalate(3), avenalumic acid methyl ester(4) by comparison of physical and spectral data with those reported in the literature. Among the isolated compounds, bis(2-methylheptyl)phthalate showed most potent inhibitory effect on the melanogenesis in cultured B-16 mouse melanoma cell lines(IC∧50, 36.8 μM) compared with kojic acid(IC∧50, 150 μM).
ISSN:0253-3073