luxS and smcR Quorum-Sension System of Vibrio vulnificus as an Important Factor for In Vivo Survival

luxS and smcR Quorum-Sension System of Vibrio vulnificus as an Important Factor for In Vivo Survival

Vibrio vulnificus is an opportunistic pathogen that causes a septicemia and expresses numerous virulence factors, in which luxS and smcR are genes encoding for components responsible for quorum-sensing regulation. In the present study, null mutants were constructed with lesions in each or both of th...

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Veröffentlicht in:Journal of microbiology and biotechnology 2005-12, Vol.15 (6)
Hauptverfasser: Shin, N.R. (Seoul National University, Seoul, Republic of Korea), Baek, C.H. (Sogang University, Seoul, Republic of Korea), Lee, D.Y. (Seoul National University, Seoul, Republic of Korea), Cho, Y.W. (Seoul National University, Seoul, Republic of Korea), Park, D.K. (Sogang University, Seoul, Republic of Korea), Lee, K.E. (Sogang University, Seoul, Republic of Korea), Kim, K.S. (Sogang University, Seoul, Republic of Korea), Yoo, H.S. (Seoul National University, Seoul, Republic of Korea), E-mail: yoohs@snu.ac.kr
Format: Artikel
Sprache:eng
Schlagworte:
luxS
smcR
VIBRIO VULNIFICUS
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Zusammenfassung:Vibrio vulnificus is an opportunistic pathogen that causes a septicemia and expresses numerous virulence factors, in which luxS and smcR are genes encoding for components responsible for quorum-sensing regulation. In the present study, null mutants were constructed with lesions in each or both of these two genes from the V. vulnificus Vv ΔZ strain, which is a lacZ∨- and chloramphenicol/streptomycin-resistant derivative of the wild-type ATCC29307 strain, and their phenotypes related to virulence were compared with those of the parental cells.
ISSN:1017-7825