Pinostrobin from Boesenbergia pandurata is an inhibitor of Ca2+ -signal-mediated cell-cycle regulation in the yeast Saccharomyces cerevisiae

Upon searching plant extracts for inhibitors of the Ca 2+ signaling pathway using the zds1Δ-yeast proliferation based assay, a crude rhizome extract of Boesenbergia pandurata was found to be strongly positive, and from this extract pinostrobin, alpinetin, and pinocembrin chalcone were isolated as ac...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2009-07, Vol.73 (7), p.1679-1682
Hauptverfasser:	Wangkangwan, W.(Chulalongkorn Univ., Bangkok (Thailand)), Boonkerd, S, Chavasiri, W, Sukapirom, K, Pattanapanyasat, K, Kongkathip, N, Miyakawa, T, Yompakdee, C
Format:	Artikel
Sprache:	eng
Schlagworte:	BIOASSAYS BIOCHEMICAL PATHWAYS Biological and medical sciences Boesenbergia pandurata CALCIO CALCIUM Calcium - metabolism Calcium Signaling - drug effects CELL CYCLE Cell Cycle - drug effects Cell Division - drug effects Chemical Fractionation CICLO CELULAR CYCLE CELLULAIRE ENSAYO BIOLOGICO EXTRACTOS VEGETALES EXTRAIT D'ORIGINE VEGETALE Flavanones - isolation & purification Flavanones - pharmacology Fundamental and applied biological sciences. Psychology G2 Phase - drug effects inhibitor Mutation PHYSIOLOGICAL REGULATION pinostrobin PLANT EXTRACTS Plant Extracts - chemistry REGULACION FISIOLOGICA REGULATION PHYSIOLOGIQUE RHIZOME RHIZOMES RIZOMAS Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism signal TEST BIOLOGIQUE VIA BIOQUIMICA DEL METABOLISMO VOIE BIOCHIMIQUE DU METABOLISME yeast based assay ZINGIBERACEAE Zingiberaceae - chemistry ZINGIBERACEAS
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Zusammenfassung:	Upon searching plant extracts for inhibitors of the Ca 2+ signaling pathway using the zds1Δ-yeast proliferation based assay, a crude rhizome extract of Boesenbergia pandurata was found to be strongly positive, and from this extract pinostrobin, alpinetin, and pinocembrin chalcone were isolated as active components. Further biochemical experiments confirmed that pinostrobin possesses inhibitory activity on the Ca 2+ signals involved in the control of G2/M phase cell cycle progression in Saccharomyces cerevisiae.
ISSN:	0916-8451 1347-6947
DOI:	10.1271/bbb.90114