Natural antioxidant, chlorogenic acid, protects against DNA breakage caused by monochloramine

Chlorogenic acid prevented a stepwise conversion of plasmid pUC18 DNA, form I→form II→form III, induced by 3 mM monochloramine with a half inhibition of 67.4 μM. Chlorogenic acid reacted with monochloramine in a time-dependent manner, and the reaction rate increased with decreasing pH. These results...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 1999-07, Vol.63 (7), p.1295-1297
Hauptverfasser:	Shibata, H. (Shimane Univ., Matsue (Japan)), Sakamoto, Y, Oka, M, Kono, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	ACIDE CHLOROGENIQUE ACIDO CLOROGENICO ADN Ammonium Chloride - chemistry ANTIOXIDANTES ANTIOXIDANTS Antioxidants - pharmacology ANTIOXYDANT Biological and medical sciences Chemical mutagenesis Chloramines - antagonists & inhibitors Chloramines - toxicity CHLOROGENIC ACID Chlorogenic Acid - pharmacology COMPOSE ORGANOCHLORE COMPUESTO ORGANICO DEL CLORO DNA DNA damage DNA Damage - drug effects DNA, Bacterial - chemistry DNA, Bacterial - drug effects gastric injury Helicobacter pylori - drug effects Helicobacter pylori - metabolism Medical sciences Monochloramine natural antioxidant ORGANOCHLORINE COMPOUNDS plasmid pUC18 Plasmids - chemistry Spectrophotometry, Ultraviolet Toxicology
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Zusammenfassung:	Chlorogenic acid prevented a stepwise conversion of plasmid pUC18 DNA, form I→form II→form III, induced by 3 mM monochloramine with a half inhibition of 67.4 μM. Chlorogenic acid reacted with monochloramine in a time-dependent manner, and the reaction rate increased with decreasing pH. These results suggest that chlorogenic acid prevents genotoxicity of monochloramine in gastric mucosa.
ISSN:	0916-8451 1347-6947
DOI:	10.1271/bbb.63.1295