Inhibitory effects of apple polyphenol on induced histamine release from RBL-2H3 cells and rat mast cells
The anti-allergic activities of polyphenol fractions extracted from immature fruits of apple (Rosaceae, Malus sp.) were evaluated by in vitro assays. A crude apple polyphenol (CAP) fraction, which had been obtained from the juice of immature apples by reverse-phase column chromatography, was further...
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| Veröffentlicht in: | Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 1998-07, Vol.62 (7), p.1284-1289 |
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| container_title | Bioscience, biotechnology, and biochemistry |
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| creator | Kanda, T. (Nikka Whisky Distilling Co. Ltd., Kashiwa, Chiba (Japan)) Akiyama, H Yanagida, A Tanabe, M Goda, Y Toyoda, M Teshima, R Saito, Y |
| description | The anti-allergic activities of polyphenol fractions extracted from immature fruits of apple (Rosaceae, Malus sp.) were evaluated by in vitro assays. A crude apple polyphenol (CAP) fraction, which had been obtained from the juice of immature apples by reverse-phase column chromatography, was further purified by LH-20 column chromatography to obtain an apple condensed tannin (ACT) fraction consisting of linear oligomeric epicatechins from the dimer to pentadecamer. ACT strongly inhibited the release of histamine from rat basophilic leukemia (RBL-2H3) cells stimulated by the antigen-stimulation and from rat peritoneal mast cells stimulated by compound 48/80. The IC50 values for histamine release were 30 mu-g/ml and 25 mu-g/ml, respectively. ACT also inhibited hyaluronidase activity and the increase in intracellular free calcium concentration in RBL-2H3 cells stimulated with the antigen. These results suggest that ACT affected early signal transduction including the calcium influx |
| doi_str_mv | 10.1271/bbb.62.1284 |
| format | Article |
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(Nikka Whisky Distilling Co. Ltd., Kashiwa, Chiba (Japan)) ; Akiyama, H ; Yanagida, A ; Tanabe, M ; Goda, Y ; Toyoda, M ; Teshima, R ; Saito, Y</creator><creatorcontrib>Kanda, T. (Nikka Whisky Distilling Co. Ltd., Kashiwa, Chiba (Japan)) ; Akiyama, H ; Yanagida, A ; Tanabe, M ; Goda, Y ; Toyoda, M ; Teshima, R ; Saito, Y</creatorcontrib><description>The anti-allergic activities of polyphenol fractions extracted from immature fruits of apple (Rosaceae, Malus sp.) were evaluated by in vitro assays. A crude apple polyphenol (CAP) fraction, which had been obtained from the juice of immature apples by reverse-phase column chromatography, was further purified by LH-20 column chromatography to obtain an apple condensed tannin (ACT) fraction consisting of linear oligomeric epicatechins from the dimer to pentadecamer. ACT strongly inhibited the release of histamine from rat basophilic leukemia (RBL-2H3) cells stimulated by the antigen-stimulation and from rat peritoneal mast cells stimulated by compound 48/80. The IC50 values for histamine release were 30 mu-g/ml and 25 mu-g/ml, respectively. ACT also inhibited hyaluronidase activity and the increase in intracellular free calcium concentration in RBL-2H3 cells stimulated with the antigen. These results suggest that ACT affected early signal transduction including the calcium influx</description><identifier>ISSN: 0916-8451</identifier><identifier>EISSN: 1347-6947</identifier><identifier>DOI: 10.1271/bbb.62.1284</identifier><identifier>PMID: 9720210</identifier><language>eng</language><publisher>Tokyo: Japan Society for Bioscience, Biotechnology, and Agrochemistry</publisher><subject>Animals ; anti-allergic activity ; Antigens ; apple polyphenol ; APPLES ; Biflavonoids ; Biological and medical sciences ; Calcium - metabolism ; calcium influx ; Catechin - pharmacology ; Chlorogenic Acid - pharmacology ; Flavonoids ; Fruit - chemistry ; General pharmacology ; HISTAMINA ; HISTAMINE ; Histamine Antagonists - isolation & purification ; Histamine Antagonists - pharmacology ; histamine release ; Histamine Release - drug effects ; hyaluronidase ; Hyaluronoglucosaminidase - antagonists & inhibitors ; Hydrolyzable Tannins - isolation & purification ; Hydrolyzable Tannins - pharmacology ; HYPERSENSITIVITY ; Leukemia, Basophilic, Acute ; MANZANA ; Mast Cells - drug effects ; Mast Cells - metabolism ; Medical sciences ; p-Methoxy-N-methylphenethylamine ; Peritoneum - drug effects ; Peritoneum - metabolism ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Phenols - isolation & purification ; Phenols - pharmacology ; Phlorhizin - pharmacology ; POLIFENOLES ; Polymers - isolation & purification ; Polymers - pharmacology ; POLYPHENOL ; POLYPHENOLS ; POMME ; Proanthocyanidins ; Rats ; REACCIONES ALERGICAS ; REACTION ALLERGIQUE ; Tumor Cells, Cultured - drug effects</subject><ispartof>Bioscience, biotechnology, and biochemistry, 1998-07, Vol.62 (7), p.1284-1289</ispartof><rights>1998 by Japan Society for Bioscience, Biotechnology, and Agrochemistry 1998</rights><rights>1998 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c602t-ebde16b2e59cdce84a5b97d78379d2de4fccbde1aecf34ff385a24d1f93ab01b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2417094$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9720210$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kanda, T. (Nikka Whisky Distilling Co. Ltd., Kashiwa, Chiba (Japan))</creatorcontrib><creatorcontrib>Akiyama, H</creatorcontrib><creatorcontrib>Yanagida, A</creatorcontrib><creatorcontrib>Tanabe, M</creatorcontrib><creatorcontrib>Goda, Y</creatorcontrib><creatorcontrib>Toyoda, M</creatorcontrib><creatorcontrib>Teshima, R</creatorcontrib><creatorcontrib>Saito, Y</creatorcontrib><title>Inhibitory effects of apple polyphenol on induced histamine release from RBL-2H3 cells and rat mast cells</title><title>Bioscience, biotechnology, and biochemistry</title><addtitle>Biosci Biotechnol Biochem</addtitle><description>The anti-allergic activities of polyphenol fractions extracted from immature fruits of apple (Rosaceae, Malus sp.) were evaluated by in vitro assays. A crude apple polyphenol (CAP) fraction, which had been obtained from the juice of immature apples by reverse-phase column chromatography, was further purified by LH-20 column chromatography to obtain an apple condensed tannin (ACT) fraction consisting of linear oligomeric epicatechins from the dimer to pentadecamer. ACT strongly inhibited the release of histamine from rat basophilic leukemia (RBL-2H3) cells stimulated by the antigen-stimulation and from rat peritoneal mast cells stimulated by compound 48/80. The IC50 values for histamine release were 30 mu-g/ml and 25 mu-g/ml, respectively. ACT also inhibited hyaluronidase activity and the increase in intracellular free calcium concentration in RBL-2H3 cells stimulated with the antigen. These results suggest that ACT affected early signal transduction including the calcium influx</description><subject>Animals</subject><subject>anti-allergic activity</subject><subject>Antigens</subject><subject>apple polyphenol</subject><subject>APPLES</subject><subject>Biflavonoids</subject><subject>Biological and medical sciences</subject><subject>Calcium - metabolism</subject><subject>calcium influx</subject><subject>Catechin - pharmacology</subject><subject>Chlorogenic Acid - pharmacology</subject><subject>Flavonoids</subject><subject>Fruit - chemistry</subject><subject>General pharmacology</subject><subject>HISTAMINA</subject><subject>HISTAMINE</subject><subject>Histamine Antagonists - isolation & purification</subject><subject>Histamine Antagonists - pharmacology</subject><subject>histamine release</subject><subject>Histamine Release - drug effects</subject><subject>hyaluronidase</subject><subject>Hyaluronoglucosaminidase - antagonists & inhibitors</subject><subject>Hydrolyzable Tannins - isolation & purification</subject><subject>Hydrolyzable Tannins - pharmacology</subject><subject>HYPERSENSITIVITY</subject><subject>Leukemia, Basophilic, Acute</subject><subject>MANZANA</subject><subject>Mast Cells - drug effects</subject><subject>Mast Cells - metabolism</subject><subject>Medical sciences</subject><subject>p-Methoxy-N-methylphenethylamine</subject><subject>Peritoneum - drug effects</subject><subject>Peritoneum - metabolism</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenols - isolation & purification</subject><subject>Phenols - pharmacology</subject><subject>Phlorhizin - pharmacology</subject><subject>POLIFENOLES</subject><subject>Polymers - isolation & purification</subject><subject>Polymers - pharmacology</subject><subject>POLYPHENOL</subject><subject>POLYPHENOLS</subject><subject>POMME</subject><subject>Proanthocyanidins</subject><subject>Rats</subject><subject>REACCIONES ALERGICAS</subject><subject>REACTION ALLERGIQUE</subject><subject>Tumor Cells, Cultured - drug effects</subject><issn>0916-8451</issn><issn>1347-6947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2LFDEQhoMo67h68iwEFC_Sa5JOdzpHXdRdGVBEzyEfFaeXdNIm3cj8e9PMuAcPnqqoeuqt4i2EnlNyRZmgb40xVz2r-cAfoB1tuWh6ycVDtCOS9s3AO_oYPSnljpBa6OgFupCCEUbJDo238TCacUn5iMF7sEvByWM9zwHwnMJxPkBMAaeIx-hWCw4fxrLoaYyAMwTQBbDPacLf3u8bdtNiCyEUrKPDWS940mU5lZ6iR16HAs_O8RL9-Pjh-_VNs__y6fb63b6xPWFLA8YB7Q2DTlpnYeC6M1I4MbRCOuaAe2s3RIP1Lfe-HTrNuKNettoQatpL9PqkO-f0a4WyqGks2wU6QlqLEnWiq2oVfPkPeJfWHOttinIuORvk0FXqzYmyOZWSwas5j5POR0WJ2uxX1X7VM7XZX-kXZ83VTODu2bPftf_q3NfF6uCzjnYs9xjjVBC5yfQnbIw-5Un_Tjk4tehjSPnvTPvf_V4npX_myn3-SqWU2-tF1_4BZE6pFg</recordid><startdate>19980701</startdate><enddate>19980701</enddate><creator>Kanda, T. (Nikka Whisky Distilling Co. Ltd., Kashiwa, Chiba (Japan))</creator><creator>Akiyama, H</creator><creator>Yanagida, A</creator><creator>Tanabe, M</creator><creator>Goda, Y</creator><creator>Toyoda, M</creator><creator>Teshima, R</creator><creator>Saito, Y</creator><general>Japan Society for Bioscience, Biotechnology, and Agrochemistry</general><general>Japan Society for Bioscience Biotechnology and Agrochemistry</general><general>Oxford University Press</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980701</creationdate><title>Inhibitory effects of apple polyphenol on induced histamine release from RBL-2H3 cells and rat mast cells</title><author>Kanda, T. (Nikka Whisky Distilling Co. Ltd., Kashiwa, Chiba (Japan)) ; Akiyama, H ; Yanagida, A ; Tanabe, M ; Goda, Y ; Toyoda, M ; Teshima, R ; Saito, Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c602t-ebde16b2e59cdce84a5b97d78379d2de4fccbde1aecf34ff385a24d1f93ab01b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>anti-allergic activity</topic><topic>Antigens</topic><topic>apple polyphenol</topic><topic>APPLES</topic><topic>Biflavonoids</topic><topic>Biological and medical sciences</topic><topic>Calcium - metabolism</topic><topic>calcium influx</topic><topic>Catechin - pharmacology</topic><topic>Chlorogenic Acid - pharmacology</topic><topic>Flavonoids</topic><topic>Fruit - chemistry</topic><topic>General pharmacology</topic><topic>HISTAMINA</topic><topic>HISTAMINE</topic><topic>Histamine Antagonists - isolation & purification</topic><topic>Histamine Antagonists - pharmacology</topic><topic>histamine release</topic><topic>Histamine Release - drug effects</topic><topic>hyaluronidase</topic><topic>Hyaluronoglucosaminidase - antagonists & inhibitors</topic><topic>Hydrolyzable Tannins - isolation & purification</topic><topic>Hydrolyzable Tannins - pharmacology</topic><topic>HYPERSENSITIVITY</topic><topic>Leukemia, Basophilic, Acute</topic><topic>MANZANA</topic><topic>Mast Cells - drug effects</topic><topic>Mast Cells - metabolism</topic><topic>Medical sciences</topic><topic>p-Methoxy-N-methylphenethylamine</topic><topic>Peritoneum - drug effects</topic><topic>Peritoneum - metabolism</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenols - isolation & purification</topic><topic>Phenols - pharmacology</topic><topic>Phlorhizin - pharmacology</topic><topic>POLIFENOLES</topic><topic>Polymers - isolation & purification</topic><topic>Polymers - pharmacology</topic><topic>POLYPHENOL</topic><topic>POLYPHENOLS</topic><topic>POMME</topic><topic>Proanthocyanidins</topic><topic>Rats</topic><topic>REACCIONES ALERGICAS</topic><topic>REACTION ALLERGIQUE</topic><topic>Tumor Cells, Cultured - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kanda, T. (Nikka Whisky Distilling Co. Ltd., Kashiwa, Chiba (Japan))</creatorcontrib><creatorcontrib>Akiyama, H</creatorcontrib><creatorcontrib>Yanagida, A</creatorcontrib><creatorcontrib>Tanabe, M</creatorcontrib><creatorcontrib>Goda, Y</creatorcontrib><creatorcontrib>Toyoda, M</creatorcontrib><creatorcontrib>Teshima, R</creatorcontrib><creatorcontrib>Saito, Y</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioscience, biotechnology, and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kanda, T. (Nikka Whisky Distilling Co. Ltd., Kashiwa, Chiba (Japan))</au><au>Akiyama, H</au><au>Yanagida, A</au><au>Tanabe, M</au><au>Goda, Y</au><au>Toyoda, M</au><au>Teshima, R</au><au>Saito, Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibitory effects of apple polyphenol on induced histamine release from RBL-2H3 cells and rat mast cells</atitle><jtitle>Bioscience, biotechnology, and biochemistry</jtitle><addtitle>Biosci Biotechnol Biochem</addtitle><date>1998-07-01</date><risdate>1998</risdate><volume>62</volume><issue>7</issue><spage>1284</spage><epage>1289</epage><pages>1284-1289</pages><issn>0916-8451</issn><eissn>1347-6947</eissn><abstract>The anti-allergic activities of polyphenol fractions extracted from immature fruits of apple (Rosaceae, Malus sp.) were evaluated by in vitro assays. A crude apple polyphenol (CAP) fraction, which had been obtained from the juice of immature apples by reverse-phase column chromatography, was further purified by LH-20 column chromatography to obtain an apple condensed tannin (ACT) fraction consisting of linear oligomeric epicatechins from the dimer to pentadecamer. ACT strongly inhibited the release of histamine from rat basophilic leukemia (RBL-2H3) cells stimulated by the antigen-stimulation and from rat peritoneal mast cells stimulated by compound 48/80. The IC50 values for histamine release were 30 mu-g/ml and 25 mu-g/ml, respectively. ACT also inhibited hyaluronidase activity and the increase in intracellular free calcium concentration in RBL-2H3 cells stimulated with the antigen. These results suggest that ACT affected early signal transduction including the calcium influx</abstract><cop>Tokyo</cop><pub>Japan Society for Bioscience, Biotechnology, and Agrochemistry</pub><pmid>9720210</pmid><doi>10.1271/bbb.62.1284</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0916-8451 |
| ispartof | Bioscience, biotechnology, and biochemistry, 1998-07, Vol.62 (7), p.1284-1289 |
| issn | 0916-8451 1347-6947 |
| language | eng |
| recordid | cdi_fao_agris_JP1999000975 |
| source | J-STAGE Free; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Freely Accessible Japanese Titles; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Animals anti-allergic activity Antigens apple polyphenol APPLES Biflavonoids Biological and medical sciences Calcium - metabolism calcium influx Catechin - pharmacology Chlorogenic Acid - pharmacology Flavonoids Fruit - chemistry General pharmacology HISTAMINA HISTAMINE Histamine Antagonists - isolation & purification Histamine Antagonists - pharmacology histamine release Histamine Release - drug effects hyaluronidase Hyaluronoglucosaminidase - antagonists & inhibitors Hydrolyzable Tannins - isolation & purification Hydrolyzable Tannins - pharmacology HYPERSENSITIVITY Leukemia, Basophilic, Acute MANZANA Mast Cells - drug effects Mast Cells - metabolism Medical sciences p-Methoxy-N-methylphenethylamine Peritoneum - drug effects Peritoneum - metabolism Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phenols - isolation & purification Phenols - pharmacology Phlorhizin - pharmacology POLIFENOLES Polymers - isolation & purification Polymers - pharmacology POLYPHENOL POLYPHENOLS POMME Proanthocyanidins Rats REACCIONES ALERGICAS REACTION ALLERGIQUE Tumor Cells, Cultured - drug effects |
| title | Inhibitory effects of apple polyphenol on induced histamine release from RBL-2H3 cells and rat mast cells |
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