PATHOGENETICAL ASPECTS IN EXPERIMENTALY INFECTED KIDS WITH BULGARIAN CAPRINE HERPES VIRUS 1 ISOLATES

Experimental intranasal and intravenous infection in six 3 - 30 days old kids with Bulgarian isolates of goat herpes virus 1, were performed. Two infected kids were eutanizated on 14 and 16 days after the virus inoculation, while the others dead fom 1 to 6 months post inoculation. Eyes, nose, vaginal and rectal tampons samples from infected kids were collected during the period of examination. Virus was reizolated succsessfully in cell cultures - Madin Darby Bovine Kidney - MDBK and Embryonal bovine trachea - EBTR from nose and rectal tampons. The disease was developed as local or generalized infection, characterised by stupor, febris, unilateral and bilateral nasal and ocular discharges, diarrhoea, blood monocytosis and high activities of transaminases enzimes - ASAT, ALAT. Thirty six samples obtained from internal organs were examinated by viral - virus izolation in cell cultures and microbiological - cultural and microscopic methods. The virus is reisolated from nose mucosa and internal organs of kids, while the result from bacterial specific diseases is negative.