2,9-Disubstituted purin-6-ones

2,9-Disubstituted purin-6-ones

2,9-disubstd. purin-6-ones of formula (I) and their tautomers and salts are new: R1 = 2-10C alkyl or phenyl(2-10C)alkyl opt. ring-substd. by halo, NO2, CN or 1-6C alkyl; R2 = H, OH, azido, 1-6C alkyl or OSO2R 5; R3 = H; or R2+R3 = O; R4 = H or 1-4C alkyl; R5 = 1-4C alkyl or phenyl; A = 3,4-methylene...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: HELMUTH SCHUETZ, ERWIN BISCHOFF, ULRICH NIEWOEHNER, ELISABETH PERZBORN, MATTHIAS SCHRAMM
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:2,9-disubstd. purin-6-ones of formula (I) and their tautomers and salts are new: R1 = 2-10C alkyl or phenyl(2-10C)alkyl opt. ring-substd. by halo, NO2, CN or 1-6C alkyl; R2 = H, OH, azido, 1-6C alkyl or OSO2R 5; R3 = H; or R2+R3 = O; R4 = H or 1-4C alkyl; R5 = 1-4C alkyl or phenyl; A = 3,4-methylenedioxyphenyl, 1-20C alkyl, 3-7C cycloalkyl, or phenyl (opt. substd. by 1-2 halo, CF3, COOH, NO2, CN, 1-5C alky, phenyl(1-5C)alkyl, 2-5C alkoxycarbonyl, phenyl(2-5C)alkoxycarbonyl, 1-5C alkoxy or phenyl(1-5C)alkoxy) and/or the rings are opt. substd. by phenyl or (1-5C)alkoxy phenyl.