New lipid esters of nucleoside monophosphates use as immunosuppresive drugs
The present invention is directed to new nucleoside monophosphate derivatives of lipid ester residues of general formula (I) wherein R may be a straight-chain or branched, saturated or unsaturated alkyl chain having 1-20 carbon atoms, R may be hydrogen, a straight-chain or branched, saturated or uns...
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| creator | HANS-GEORG OPTIZ HARALD ZILCH ALFRED MERTENS DIETER HERRMANN |
| description | The present invention is directed to new nucleoside monophosphate derivatives of lipid ester residues of general formula (I) wherein R may be a straight-chain or branched, saturated or unsaturated alkyl chain having 1-20 carbon atoms, R may be hydrogen, a straight-chain or branched, saturated or unsaturated alkyl chain having 1-20 carbon atoms, X represents sulfur, a sulfinyl or sulfonyl group;and Nucl. represents 2',3'-Didesoxy-2',3'-difluorothymidine 2'-Desoxy-2'-aminoadenosine 2'-Desoxy-2'-azidoadenosine 2'-Desoxy-2'-azidocytidine 2'-Desoxy-5-fluorouridine 2-Fluoro-2'-desoxyadenosine their tautomers and their physiologically acceptable salts of inorganic and organic acids and/or bases, as well as to processes for their preparation, and to drugs containing said compounds. |
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DERIVATIVES THEREOF ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SUGARS</subject><creationdate>1996</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19961129&DB=EPODOC&CC=ZA&NR=954374B$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19961129&DB=EPODOC&CC=ZA&NR=954374B$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HANS-GEORG OPTIZ</creatorcontrib><creatorcontrib>HARALD ZILCH</creatorcontrib><creatorcontrib>ALFRED MERTENS</creatorcontrib><creatorcontrib>DIETER HERRMANN</creatorcontrib><title>New lipid esters of nucleoside monophosphates use as immunosuppresive drugs</title><description>The present invention is directed to new nucleoside monophosphate derivatives of lipid ester residues of general formula (I) wherein R may be a straight-chain or branched, saturated or unsaturated alkyl chain having 1-20 carbon atoms, R may be hydrogen, a straight-chain or branched, saturated or unsaturated alkyl chain having 1-20 carbon atoms, X represents sulfur, a sulfinyl or sulfonyl group;and Nucl. represents 2',3'-Didesoxy-2',3'-difluorothymidine 2'-Desoxy-2'-aminoadenosine 2'-Desoxy-2'-azidoadenosine 2'-Desoxy-2'-azidocytidine 2'-Desoxy-5-fluorouridine 2-Fluoro-2'-desoxyadenosine their tautomers and their physiologically acceptable salts of inorganic and organic acids and/or bases, as well as to processes for their preparation, and to drugs containing said compounds.</description><subject>CHEMISTRY</subject><subject>DERIVATIVES THEREOF</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SUGARS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1996</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFyrEKwjAUBdAuDqL-grwfcGpFHFUUQXBycimhvbWBJu-Rm-jvu7g7neXMq9sdH5m8-V7AjETRQWLpJih9Dwka1UaljS6DUghxFB9CicpilkD_hvSpvLisZoObiNXPRbW-nB-n6wamLWiuQ0Run4f9tql3zbH-G76CDjU9</recordid><startdate>19961129</startdate><enddate>19961129</enddate><creator>HANS-GEORG OPTIZ</creator><creator>HARALD ZILCH</creator><creator>ALFRED MERTENS</creator><creator>DIETER HERRMANN</creator><scope>EVB</scope></search><sort><creationdate>19961129</creationdate><title>New lipid esters of nucleoside monophosphates use as immunosuppresive drugs</title><author>HANS-GEORG OPTIZ ; HARALD ZILCH ; ALFRED MERTENS ; DIETER HERRMANN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_ZA954374B3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1996</creationdate><topic>CHEMISTRY</topic><topic>DERIVATIVES THEREOF</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SUGARS</topic><toplevel>online_resources</toplevel><creatorcontrib>HANS-GEORG OPTIZ</creatorcontrib><creatorcontrib>HARALD ZILCH</creatorcontrib><creatorcontrib>ALFRED MERTENS</creatorcontrib><creatorcontrib>DIETER HERRMANN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HANS-GEORG OPTIZ</au><au>HARALD ZILCH</au><au>ALFRED MERTENS</au><au>DIETER HERRMANN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>New lipid esters of nucleoside monophosphates use as immunosuppresive drugs</title><date>1996-11-29</date><risdate>1996</risdate><abstract>The present invention is directed to new nucleoside monophosphate derivatives of lipid ester residues of general formula (I) wherein R may be a straight-chain or branched, saturated or unsaturated alkyl chain having 1-20 carbon atoms, R may be hydrogen, a straight-chain or branched, saturated or unsaturated alkyl chain having 1-20 carbon atoms, X represents sulfur, a sulfinyl or sulfonyl group;and Nucl. represents 2',3'-Didesoxy-2',3'-difluorothymidine 2'-Desoxy-2'-aminoadenosine 2'-Desoxy-2'-azidoadenosine 2'-Desoxy-2'-azidocytidine 2'-Desoxy-5-fluorouridine 2-Fluoro-2'-desoxyadenosine their tautomers and their physiologically acceptable salts of inorganic and organic acids and/or bases, as well as to processes for their preparation, and to drugs containing said compounds.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS |
| title | New lipid esters of nucleoside monophosphates use as immunosuppresive drugs |
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