New lipid esters of nucleoside monophosphates use as immunosuppresive drugs

New lipid esters of nucleoside monophosphates use as immunosuppresive drugs

The present invention is directed to new nucleoside monophosphate derivatives of lipid ester residues of general formula (I) wherein R may be a straight-chain or branched, saturated or unsaturated alkyl chain having 1-20 carbon atoms, R may be hydrogen, a straight-chain or branched, saturated or uns...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: HANS-GEORG OPTIZ, HARALD ZILCH, ALFRED MERTENS, DIETER HERRMANN
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The present invention is directed to new nucleoside monophosphate derivatives of lipid ester residues of general formula (I) wherein R may be a straight-chain or branched, saturated or unsaturated alkyl chain having 1-20 carbon atoms, R may be hydrogen, a straight-chain or branched, saturated or unsaturated alkyl chain having 1-20 carbon atoms, X represents sulfur, a sulfinyl or sulfonyl group;and Nucl. represents 2',3'-Didesoxy-2',3'-difluorothymidine 2'-Desoxy-2'-aminoadenosine 2'-Desoxy-2'-azidoadenosine 2'-Desoxy-2'-azidocytidine 2'-Desoxy-5-fluorouridine 2-Fluoro-2'-desoxyadenosine their tautomers and their physiologically acceptable salts of inorganic and organic acids and/or bases, as well as to processes for their preparation, and to drugs containing said compounds.