Imidazole 5-position substituted angiotensin II antagonists

Imidazole 5-position substituted angiotensin II antagonists

Novel substituted imidazoles of Formula (III), which are useful as angiotensin-II antagonists, are disclosed: (III) These compounds, exemplified by the compound 1-((2'-((i-Amyloxycarbonylamino)sulfonyl)-3-fluoro-(1,1'-biphenyl)-4-yl)methyl)-5-[2-(N-butyryl-N-pyridin-3-ylamino) ethylcarbony...

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Bibliographische Detailangaben
Hauptverfasser: RICHARD ERIC OLSON, MARY KATHERINE VANATTEN, JOHN JONAS VYTAUTAS DUNCIA, CAROL LEE ENSINGER, JOSEPH BASIL SANTELLA III, MIMI LIFEN QUAN
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Novel substituted imidazoles of Formula (III), which are useful as angiotensin-II antagonists, are disclosed: (III) These compounds, exemplified by the compound 1-((2'-((i-Amyloxycarbonylamino)sulfonyl)-3-fluoro-(1,1'-biphenyl)-4-yl)methyl)-5-[2-(N-butyryl-N-pyridin-3-ylamino) ethylcarbonyl]-4-ethyl-2-propyl-1H-imidazole, are useful as antihypertensive agents.