Imidazolyl-substituted phenylacetamides

Imidazolyl-substituted phenylacetamides

Imidazolyl-substituted phenylacetamides of the general formula in which A represents straight-chain or branched alkyl or alkenyl, each of which has up to 8 carbon atoms, or represents cycloalkyl having 3 to 8 carbon atoms, B represents hydrogen, halogen or perfluoroalkyl having up to 5 carbon atoms,...

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Hauptverfasser: DR ULRICH E MUELLER, DR OEZKAN YALKINOGLU, DR ANDREAS KNORR, PH D JUERGEN DRESSEL, DR WALTER HUEBSCH, DR JOHANNES-PETER STASCH, DR MATTHIAS MUELLER-GLIEMANN, DR ULRICH NIEWOEHNER, DR PETER FEY, PROFSTANISLAV KAZDA, DR RUDOLF HANKO, DR THOMAS KRAEMER, DR MARTIN BEUCK, DR STEFAN WOHLFEIL
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Imidazolyl-substituted phenylacetamides of the general formula in which A represents straight-chain or branched alkyl or alkenyl, each of which has up to 8 carbon atoms, or represents cycloalkyl having 3 to 8 carbon atoms, B represents hydrogen, halogen or perfluoroalkyl having up to 5 carbon atoms, D represents a group of the formula -CH2OR , -CO-R , -CO-NR R , or , E represents hydrogen, halogen, nitro, hydroxyl, trifluoromethyl, trifluoromethoxy, straight-chain or branched alkyl, alkoxy or alkoxycarbonyl, each of which has up to 6 carbon atoms, cyano or carboxyl, L represents straight-chain or branched alkyl having up to 8 carbon atoms which is optionally substituted by cycloalkyl having 3 to 8 carbon atoms or phenyl, or represents cycloalkyl having 3 to 12 carbon atoms which is optionally substituted by straight-chain or branched alkyl having up to 6 carbon atoms, R represents hydrogen or straight-chain or branched alkyl having up to 8 carbon atoms, R represents a radical of the formula -C(CH3)2-CH2OH, and salts thereof. The compounds are angiotensin-II antagonists and can be used as active substances in pharmaceuticals, in particular for the treatment of hypertension and atherosclerosis.