OIL-IN-WATER-EMULSION OF AN X-RAY CONTRACT MEDIUM

The invention relates to a parenterally administrable, heat-sterilisable O/W emulsion of an X-ray contrast agent with an inner phase of one or more suitable oil-soluble organic iodine compounds, especially iodised fatty acid esters, one or more emulsifiers and, where appropriate, co-emulsifiers and...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: HEINO FOTH, BERND ESCHENBACH, KLAUS SOMMERMEYER
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The invention relates to a parenterally administrable, heat-sterilisable O/W emulsion of an X-ray contrast agent with an inner phase of one or more suitable oil-soluble organic iodine compounds, especially iodised fatty acid esters, one or more emulsifiers and, where appropriate, co-emulsifiers and an outer phase of distilled water with isotonising additives, characterised by a content of a physiologically acceptable buffer of caustic soda and one or more suitable inorganic and/or organic phosphates. The emulsions obtained are distinguished by good shelf life and heat stability and can therefore be sterilised in autoclaves at 121C.