IN VIVO TARGETING WITH BIFUNCTIONAL ANTIBODIES

This invention belongs to the field of immunology and provides a method for designing and constructing bispecific antibodies whose binding profiles are more desirable than those of the monospecific antibodies from which they were derived. The invention is exemplified in part by a bispecific antibody...

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Bibliographische Detailangaben
Hauptverfasser:	DAVID ARTHUR JOHNSON, REBECCA ANNE OWENS
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	This invention belongs to the field of immunology and provides a method for designing and constructing bispecific antibodies whose binding profiles are more desirable than those of the monospecific antibodies from which they were derived. The invention is exemplified in part by a bispecific antibody type that preferentially binds to some carcinomas and, at the same time, achieves a much decreased cross-reactivity with critical normal tissue as compared to the parent antibodies. The invention is not limited to cancer therapy, and its scope envisions the ability to selectively direct a wide variety of agents to particular sites in the body for an assortment of purposes while reducing the level of cross-reactivity to undesired locations.