NOVEL VACCINE

A variant HBsAg protein of fragment thereof displaying the antigenicity of Hepatitis B virus surface antigen is disclosed, in which the variant protein or fragment thereof (vHBsAg) comprises a modified a determinant in which there is an amino acid other than glycine at position 145 of the HBsAg sequ...

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Bibliographische Detailangaben
Hauptverfasser: WILLIAM FREDERICK CARMAN, HOWARD CHRISTOPHER THOMAS
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:A variant HBsAg protein of fragment thereof displaying the antigenicity of Hepatitis B virus surface antigen is disclosed, in which the variant protein or fragment thereof (vHBsAg) comprises a modified a determinant in which there is an amino acid other than glycine at position 145 of the HBsAg sequence. A vaccine comprising the vHBsAg is provided, as it is a kit for diagnostic in vitro detection of anti-vHBsAg antibodies and an antibody preparation comprising anti-vHBsAg antibodies.