PROCESS FOR THE PREPARATION OF 1-HYDROXYALKYL-5-NITROIMIDAZOLES

PROCESS FOR THE PREPARATION OF 1-HYDROXYALKYL-5-NITROIMIDAZOLES

Process for preparing hydroxyalkyl-1 nitro-5 imidazoles of the general formula (I) by the action of an alkylene oxide on a complex of sulphuric anhydride with a derivative of imidazole of the general formula (II) followed by the acid hydrolysis or alcoholysis of the product obtained. In the general...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: BERNADETTE MANDARD-CAZIN, MICHEL LAVIGNE
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Process for preparing hydroxyalkyl-1 nitro-5 imidazoles of the general formula (I) by the action of an alkylene oxide on a complex of sulphuric anhydride with a derivative of imidazole of the general formula (II) followed by the acid hydrolysis or alcoholysis of the product obtained. In the general formulae (I) and (II), R is hydrogen, phenyalkyl or phenyl (possibly substitued). In the general formula (I), n is 2 or 3 and one or more carbon atoms of the alkylene chain may be substitued by one or more methyl radicals. In the general formula (II), X is a group which may be eliminated by acid hydrolysis or alcoholysis.