SALTS

SALTS

The invention relates to new 7-oxo-PGI2-ephedrine salt analogues of the Formula I wherein A stands for -(CH2)2-, cis or trans -CH=CH- or -C 3BOND C-; R1 is lower alkyl or hydrogen; B represents a chemical bond, -CH2- or -CR2R3; R2 stands for lower alkyl or hydrogen; R3 represents lower alkyl or hydr...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: PETER KOERMOECZY, PAL HADHAZY, KAROLY KANAI, GYOERGY DORMAN, GEZA GALAMBOS, GABOR KOVACS, PETER GYOERY, JENOE MARTON, GYULA PAPP, ISTVAN TOEMOESKOEZI, LASZLO SZEKERES, ISTVAN STADLER, EVA UDVARY
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention relates to new 7-oxo-PGI2-ephedrine salt analogues of the Formula I wherein A stands for -(CH2)2-, cis or trans -CH=CH- or -C 3BOND C-; R1 is lower alkyl or hydrogen; B represents a chemical bond, -CH2- or -CR2R3; R2 stands for lower alkyl or hydrogen; R3 represents lower alkyl or hydrogen; X is a chemical bond, -O- or -CH2-; R4 stands for C1-6 alkyl, C4-7 cycloalkyl, C1-6 fluoroalkyl, C2-6 alkenyl, C2-6 alkynyl, phenyl, substituted phenyl or heteroaryl. The salts of the Formula I show the same pharmacological profile as the sodium salt of PGI2, they inhibit blood aggregation and the secretion of gastric acid, are useful in the prevention of anginal attacks. Accordingly the salts of the present invention are useful in the prevention of peripheral vascular diseases, in improving circulation of extremities, in relieving the seriousness of cardiac infarction and also in the treatment and prevention of gastrointestinal ulcer and acute or chronical liver injury.