PYRAZOLE DERIVATIVES WITH AN ERGOLINE SKELETON,THEIR ACID ADDITION SALTS,AND A PROCESS FOR THE PREPARATION THEREOF

PYRAZOLE DERIVATIVES WITH AN ERGOLINE SKELETON,THEIR ACID ADDITION SALTS,AND A PROCESS FOR THE PREPARATION THEREOF

The subject matter of the application are pyrazole derivatives with an ergoline skeleton of general formula wherein x...y stands for a group of formula R means a hydrogen atom or a methyl group, R1 represents a hydrogen atom or a C1-4-alkyl, carbethoxy or pyridyl group and either R2 stands for a hyd...

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Bibliographische Detailangaben
Hauptverfasser: ERZSEBET MAGO NEE KARACSONY, ALIZ DRUGA, LAJOS TOLDY, ANDRIAS RONAI, GYOERGY CSEH, ILONA BERZETEI, JOZSEF BORSY, TIVADAR RETTEGI
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The subject matter of the application are pyrazole derivatives with an ergoline skeleton of general formula wherein x...y stands for a group of formula R means a hydrogen atom or a methyl group, R1 represents a hydrogen atom or a C1-4-alkyl, carbethoxy or pyridyl group and either R2 stands for a hydrogen atom or a C1-4-alkyl, allyl, C2-4-oxoalkyl, C2-4-hydroxyalkyl or C2-4-hydroxyiminoalkyl group and R3 means a hydrogen atom or a C1-4-alkyl, hydroxy or pyridyl group or R2 and R3 together stand for a group of general formula II of claim 1, as well as their salts as well as a process for preparing them and pharmaceutical compositions containing these compounds. The above compounds above all are potent PGF2 alpha receptor antagonists.