SALTS OF DIHALO-3,4-DIHYDRO-3-OXO-2-QUINOXALINE CARBOXYLIC ACIDS AND HINDERED AMINES

There is described novel hindered amine salts of 6,7 dihalo-3,4-dihydro-3 -oxo-2-quinoxaline carboxylic acids of the formula I: wherein R and R are independently halogen: R is H, CH3, or C2H5; R , when taken singly, is H, CH3, C2H4OH, CH2C6H5 or CH2COOC2H5; R , when taken singly, is a hindered hydro...

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Hauptverfasser: DELONG D, RIAZ FAZAL ABDULLA
Format: Patent
Sprache:eng
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Zusammenfassung:There is described novel hindered amine salts of 6,7 dihalo-3,4-dihydro-3 -oxo-2-quinoxaline carboxylic acids of the formula I: wherein R and R are independently halogen: R is H, CH3, or C2H5; R , when taken singly, is H, CH3, C2H4OH, CH2C6H5 or CH2COOC2H5; R , when taken singly, is a hindered hydrocarbyl radical of the group consisting of cycloactyl, norbornyl. Ad and CHR Ad wherein Ad is a 1-adamantyl, a 2-adamantyl, a 3-(4-homoiso) twistane or a tricycloundecane radical; and R and R when taken together with the nitrogen to which they are attached, form an adamantylspiropyrrolidine radical. The compounds are prepared by treatment of the free acid with the free base or a salt of the appropriate hindered amine. They are effective antiviral agents in mammels.