NAPHTALENE DERIVATIVES

NAPHTALENE DERIVATIVES

Naphthalene derivs. of formula (I) (including racemates and enantiomers when R1 = Me) and their pharmaceutically acceptable acid addition salts are new. (R' is H or Me; Z is O, S, SO, SO2 or NR1; R1 is H, alkyl, CONR2R3, CO2R2, COR2 or SO2R2; R2 and R3 are each H, 1-4C alkyl, Ph or CF3). (I) ha...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: GALTIER D, PURCELL T, SHROOT B
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Naphthalene derivs. of formula (I) (including racemates and enantiomers when R1 = Me) and their pharmaceutically acceptable acid addition salts are new. (R' is H or Me; Z is O, S, SO, SO2 or NR1; R1 is H, alkyl, CONR2R3, CO2R2, COR2 or SO2R2; R2 and R3 are each H, 1-4C alkyl, Ph or CF3). (I) have analgesic, antiinflammatory and/or antipyretic activity. They can be used in human or veterinary medicine, e.g. for treatment of arthritis. Daily dose is 200-4000 mg, orally, parenterally or rectally. LD50 is >1000 mg/kg mouse p.o. and ED40 in the rat paw carragheenin oedema test is 15-200 mg/kg p.o.