IMPROVEMENTS IN OR RELATING TO ORGANIC COMPOUNDS

Antibiotic S 31794/F-1 (I) is a new cpd. produced by (a) cultivating a (I)-producing strain of the fungus Acrophialophora limonispora nov. spec. Dreyfuss et Muller on or in a nutrient medium and (b) isolating (I) from the fermentation broth and purifying inconventional manner. Fermentation broths ob...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	TSCHERTER H, DREYFUSS M
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPIRITS VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Antibiotic S 31794/F-1 (I) is a new cpd. produced by (a) cultivating a (I)-producing strain of the fungus Acrophialophora limonispora nov. spec. Dreyfuss et Muller on or in a nutrient medium and (b) isolating (I) from the fermentation broth and purifying inconventional manner. Fermentation broths obtained in the cultivation of (I)-producing strains of A. limonispora are also novel products. (I) has antimicrobial activity, particularly against yeasts and fungi. It has no activity against usual Gram-positive and Gram-negative bacteria. The activity of (I) against Candida strains pathogenic to humans if particularly marked. This, in serial dilution tests using 2% malt extact, pH 5.2-5.4. with incubation for 48-72 hrs. at 27 degrees, (I) has MIC's of 0.3, 1,32, 100 and 100 against Candida albicans, Candida Krusei, Trichophyton mentagrophytes, Sporotrichum schenkii and Neurospora crassa, respectively. (I) shows activity in vivo tests for activity against Candida albicans sepsis.