IMPROVEMENTS RELATING TO 2-AMINOALKYL-AMINO-THIENO(3,2-D)PYRIMIDINES

IMPROVEMENTS RELATING TO 2-AMINOALKYL-AMINO-THIENO(3,2-D)PYRIMIDINES

2-Aminoalkylamino-thieno 3,2-d pyrimidines Novel cpds of formula (I): (where R1 and R2 are H, 1-6C alkyl, or NR1r2 is a satd. monocyclic 5-7 membered heterocyclic gp. opt. interrupted by O or N and opt. substd. by an alkyl or OH gp. R3 and R4 are H or 1-6C alkyl, A is 2-10C alkylene) and their non-t...

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Bibliographische Detailangaben
Hauptverfasser: SCHROETER W, WOITUN E, NARR B
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:2-Aminoalkylamino-thieno 3,2-d pyrimidines Novel cpds of formula (I): (where R1 and R2 are H, 1-6C alkyl, or NR1r2 is a satd. monocyclic 5-7 membered heterocyclic gp. opt. interrupted by O or N and opt. substd. by an alkyl or OH gp. R3 and R4 are H or 1-6C alkyl, A is 2-10C alkylene) and their non-toxic acid addn. salts have cardiovascular and/or sedative activity, esp. for inhibiting thromocyti aggregation. They may be prepd. (a) by reacting H2N-A-N(R3)H with the corresp. 2-halo-thienopyrimidine cpd. (b) reacting HNR1R2 with the corresp. H-halo cpd. or (c) treating the corresp. 2-halo-alkylamino cpd. with NH3 or an amide or imide.